Ontology highlight
ABSTRACT:
SUBMITTER: Yoon JH
PROVIDER: S-EPMC4699387 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Genes & development 20151201 24
Translesion synthesis (TLS) DNA polymerases (Pols) promote replication through DNA lesions; however, little is known about the protein factors that affect their function in human cells. In yeast, Rev1 plays a noncatalytic role as an indispensable component of Polζ, and Polζ together with Rev1 mediates a highly mutagenic mode of TLS. However, how Rev1 functions in TLS and mutagenesis in human cells has remained unclear. Here we determined the role of Rev1 in TLS opposite UV lesions in human and m ...[more]