Ontology highlight
ABSTRACT:
SUBMITTER: Lee T
PROVIDER: S-EPMC4699421 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Lee Taegyo T Wilson Tyler W TW Berg Robert R Ryberg Per P Hartwig John F JF
Journal of the American Chemical Society 20150520 21
We report a Rh-catalyzed, enantioselective silylation of arene C-H bonds directed by a (hydrido)silyl group. (Hydrido)silyl ethers that are formed in situ by hydrosilylation of benzophenone or its derivatives undergo asymmetric C-H silylation in high yield with excellent enantioselectivity in the presence of [Rh(cod)Cl]2 and a chiral bisphosphine ligand. The stereoselectivity of this process also allows enantioenriched diarylmethanols to react with site selectivity at one aryl group over the oth ...[more]