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Enzyme-Responsive Nanoparticles for Targeted Accumulation and Prolonged Retention in Heart Tissue after Myocardial Infarction.

ABSTRACT: A method for targeting to and retaining intravenously injected nanoparticles at the site of acute myocardial infarction in a rat model is described. Enzyme-responsive peptide-polymer amphiphiles are assembled as spherical micellar nanoparticles, and undergo a morphological transition from spherical-shaped, discrete materials to network-like assemblies when acted upon by matrix metalloproteinases (MMP-2 and MMP-9), which are up-regulated in heart tissue post-myocardial infarction.

SUBMITTER: Nguyen MM

PROVIDER: S-EPMC4699559 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

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Enzyme-Responsive Nanoparticles for Targeted Accumulation and Prolonged Retention in Heart Tissue after Myocardial Infarction.

Nguyen Mary M MM Carlini Andrea S AS Chien Miao-Ping MP Sonnenberg Sonya S Luo Colin C Braden Rebecca L RL Osborn Kent G KG Li Yiwen Y Gianneschi Nathan C NC Christman Karen L KL

Advanced materials (Deerfield Beach, Fla.) 20150825 37

A method for targeting to and retaining intravenously injected nanoparticles at the site of acute myocardial infarction in a rat model is described. Enzyme-responsive peptide-polymer amphiphiles are assembled as spherical micellar nanoparticles, and undergo a morphological transition from spherical-shaped, discrete materials to network-like assemblies when acted upon by matrix metalloproteinases (MMP-2 and MMP-9), which are up-regulated in heart tissue post-myocardial infarction. ...[more]

PMID: 26305446

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