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Therapeutic Enzyme-Responsive Nanoparticles for Targeted Delivery and Accumulation in Tumors.

ABSTRACT: An enzyme-responsive, paclitaxel-loaded nanoparticle is described and assessed in vivo in a human fibrosarcoma murine xenograft. This work represents a proof-of-concept study demonstrating the utility of enzyme-responsive nanoscale drug carriers capable of targeted accumulation and retention in tumor tissue in response to overexpressed endogenous enzymes.

SUBMITTER: Callmann CE 

PROVIDER: S-EPMC4699560 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature

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Therapeutic Enzyme-Responsive Nanoparticles for Targeted Delivery and Accumulation in Tumors.

Callmann Cassandra E CE   Barback Christopher V CV   Thompson Matthew P MP   Hall David J DJ   Mattrey Robert F RF   Gianneschi Nathan C NC  

Advanced materials (Deerfield Beach, Fla.) 20150714 31

An enzyme-responsive, paclitaxel-loaded nanoparticle is described and assessed in vivo in a human fibrosarcoma murine xenograft. This work represents a proof-of-concept study demonstrating the utility of enzyme-responsive nanoscale drug carriers capable of targeted accumulation and retention in tumor tissue in response to overexpressed endogenous enzymes. ...[more]

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