Bacterial Proliferation: Keep Dividing and Don't Mind the Gap.
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ABSTRACT:
SUBMITTER: Laureti L
PROVIDER: S-EPMC4699847 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
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Bacterial Proliferation: Keep Dividing and Don't Mind the Gap.
Laureti Luisa L Demol Julien J Fuchs Robert P RP Pagès Vincent V
PLoS genetics 20151229 12
DNA Damage Tolerance (DDT) mechanisms help dealing with unrepaired DNA lesions that block replication and challenge genome integrity. Previous in vitro studies showed that the bacterial replicase is able to re-prime downstream of a DNA lesion, leaving behind a single-stranded DNA gap. The question remains of what happens to this gap in vivo. Following the insertion of a single lesion in the chromosome of a living cell, we showed that this gap is mostly filled in by Homology Directed Gap Repair i ...[more]
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