Ontology highlight
ABSTRACT:
SUBMITTER: Lin X
PROVIDER: S-EPMC4699922 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Lin Xubo X Li Zhenlong Z Gorfe Alemayehu A AA
Biophysical journal 20151201 12
Dynamic clusters of lipid-anchored Ras proteins are important for high-fidelity signal transduction in cells. The average size of Ras nanoclusters was reported to be independent of protein expression levels, and cholesterol depletion is commonly used to test the raft-preference of nanoclusters. However, whether protein concentration and membrane domain stability affect Ras clustering in a reversible manner is not well understood. We used coarse-grained molecular dynamics simulations to examine t ...[more]