Ontology highlight
ABSTRACT:
SUBMITTER: Zhou Y
PROVIDER: S-EPMC5653213 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Zhou Yong Y Prakash Priyanka P Liang Hong H Cho Kwang-Jin KJ Gorfe Alemayehu A AA Hancock John F JF
Cell 20161229 1-2
K-Ras is targeted to the plasma membrane by a C-terminal membrane anchor that comprises a farnesyl-cysteine-methyl-ester and a polybasic domain. We used quantitative spatial imaging and atomistic molecular dynamics simulations to examine molecular details of K-Ras plasma membrane binding. We found that the K-Ras anchor binds selected plasma membrane anionic lipids with defined head groups and lipid side chains. The precise amino acid sequence and prenyl group define a combinatorial code for lipi ...[more]