Ontology highlight
ABSTRACT:
SUBMITTER: Edmonds MD
PROVIDER: S-EPMC4701567 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Edmonds Mick D MD Boyd Kelli L KL Moyo Tamara T Mitra Ramkrishna R Duszynski Robert R Arrate Maria Pia MP Chen Xi X Zhao Zhongming Z Blackwell Timothy S TS Andl Thomas T Eischen Christine M CM
The Journal of clinical investigation 20151214 1
MicroRNA (miR) are important regulators of gene expression, and aberrant miR expression has been linked to oncogenesis; however, little is understood about their contribution to lung tumorigenesis. Here, we determined that miR-31 is overexpressed in human lung adenocarcinoma and this overexpression independently correlates with decreased patient survival. We developed a transgenic mouse model that allows for lung-specific expression of miR-31 to test the oncogenic potential of miR-31 in the lung ...[more]