Ontology highlight
ABSTRACT:
SUBMITTER: Fitzhugh CD
PROVIDER: S-EPMC4702259 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Fitzhugh C D CD Weitzel R P RP Hsieh M M MM Phang O A OA Madison C C Luznik L L Powell J D JD Tisdale J F JF
Bone marrow transplantation 20130422 10
Because of the toxicity associated with myeloablative conditioning, nonmyeloablative regimens are increasingly being used in vulnerable patient populations. For patients with sickle cell disease, stable mixed chimerism has proven sufficient to reverse the phenotype. Because the vast majority of patients do not have an HLA-matched sibling, a safe nonmyeloablative regimen that could be applied to the haploidentical setting would be ideal. We employed a mismatched mouse model using BALB/c donors an ...[more]