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An essential cell cycle regulation gene causes hybrid inviability in Drosophila.

ABSTRACT: Speciation, the process by which new biological species arise, involves the evolution of reproductive barriers, such as hybrid sterility or inviability between populations. However, identifying hybrid incompatibility genes remains a key obstacle in understanding the molecular basis of reproductive isolation. We devised a genomic screen, which identified a cell cycle-regulation gene as the cause of male inviability in hybrids resulting from a cross between Drosophila melanogaster and D. simulans. Ablation of the D. simulans allele of this gene is sufficient to rescue the adult viability of hybrid males. This dominantly acting cell cycle regulator causes mitotic arrest and, thereby, inviability of male hybrid larvae. Our genomic method provides a facile means to accelerate the identification of hybrid incompatibility genes in other model and nonmodel systems.

SUBMITTER: Phadnis N

PROVIDER: S-EPMC4703311 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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An essential cell cycle regulation gene causes hybrid inviability in Drosophila.

Phadnis Nitin N Baker EmilyClare P EP Cooper Jacob C JC Frizzell Kimberly A KA Hsieh Emily E de la Cruz Aida Flor A AF Shendure Jay J Kitzman Jacob O JO Malik Harmit S HS

Science (New York, N.Y.) 20151201 6267

Speciation, the process by which new biological species arise, involves the evolution of reproductive barriers, such as hybrid sterility or inviability between populations. However, identifying hybrid incompatibility genes remains a key obstacle in understanding the molecular basis of reproductive isolation. We devised a genomic screen, which identified a cell cycle-regulation gene as the cause of male inviability in hybrids resulting from a cross between Drosophila melanogaster and D. simulans. ...[more]

PMID: 26680200

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