Ontology highlight
ABSTRACT:
SUBMITTER: Halabi NM
PROVIDER: S-EPMC4703369 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Halabi Najeeb M NM Martinez Alejandra A Al-Farsi Halema H Mery Eliane E Puydenus Laurence L Pujol Pascal P Khalak Hanif G HG McLurcan Cameron C Ferron Gwenael G Querleu Denis D Al-Azwani Iman I Al-Dous Eman E Mohamoud Yasmin A YA Malek Joel A JA Rafii Arash A
PLoS genetics 20160106 1
Identifying genes where a variant allele is preferentially expressed in tumors could lead to a better understanding of cancer biology and optimization of targeted therapy. However, tumor sample heterogeneity complicates standard approaches for detecting preferential allele expression. We therefore developed a novel approach combining genome and transcriptome sequencing data from the same sample that corrects for sample heterogeneity and identifies significant preferentially expressed alleles. We ...[more]