Ontology highlight
ABSTRACT:
SUBMITTER: Swanson KD
PROVIDER: S-EPMC4703612 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Swanson Kenneth D KD Lok Edwin E Wong Eric T ET
Current neurology and neuroscience reports 20160101 1
As with many cancer treatments, tumor treating fields (TTFields) target rapidly dividing tumor cells. During mitosis, TTFields-exposed cells exhibit uncontrolled membrane blebbing at the onset of anaphase, resulting in aberrant mitotic exit. Based on these criteria, at least two protein complexes have been proposed as TTFields' molecular targets, including α/β-tubulin and the septin 2, 6, 7 heterotrimer. After aberrant mitotic exit, cells exhibited abnormal nuclei and signs of cellular stress, i ...[more]