Ontology highlight
ABSTRACT:
SUBMITTER: Hontelez S
PROVIDER: S-EPMC4703837 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Nature communications 20151218
Histone-modifying enzymes are required for cell identity and lineage commitment, however little is known about the regulatory origins of the epigenome during embryonic development. Here we generate a comprehensive set of epigenome reference maps, which we use to determine the extent to which maternal factors shape chromatin state in Xenopus embryos. Using α-amanitin to inhibit zygotic transcription, we find that the majority of H3K4me3- and H3K27me3-enriched regions form a maternally defined epi ...[more]