Ontology highlight
ABSTRACT:
SUBMITTER: Vincendeau M
PROVIDER: S-EPMC4703965 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Vincendeau Michelle M Hadian Kamyar K Messias Ana C AC Brenke Jara K JK Halander Jenny J Griesbach Richard R Greczmiel Ute U Bertossi Arianna A Stehle Ralf R Nagel Daniel D Demski Katrin K Velvarska Hana H Niessing Dierk D Geerlof Arie A Sattler Michael M Krappmann Daniel D
Scientific reports 20160107
The IκB kinase (IKK) complex acts as the gatekeeper of canonical NF-κB signaling, thereby regulating immunity, inflammation and cancer. It consists of the catalytic subunits IKKα and IKKβ and the regulatory subunit NEMO/IKKγ. Here, we show that the ubiquitin binding domain (UBAN) in NEMO is essential for IKK/NF-κB activation in response to TNFα, but not IL-1β stimulation. By screening a natural compound library we identified an anthraquinone derivative that acts as an inhibitor of NEMO-ubiquitin ...[more]