Ontology highlight
ABSTRACT:
SUBMITTER: Jackson SS
PROVIDER: S-EPMC4302062 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Jackson Shawn S SS Oberley Christopher C Hooper Christopher P CP Grindle Kreg K Wuerzberger-Davis Shelly S Wolff Jared J McCool Kevin K Rui Lixin L Miyamoto Shigeki S
Experimental cell research 20141007 1
The NF-κB family of transcription factors regulates numerous cellular processes, including cell proliferation and survival responses. The constitutive activation of NF-κB has also emerged as an important oncogenic driver in many malignancies, such as activated B-cell like diffuse large B cell lymphoma, among others. In this study, we investigated the impact and mechanisms of action of Withaferin A, a naturally produced steroidal lactone, against both signal-inducible as well as constitutive NF-κ ...[more]