Ontology highlight
ABSTRACT:
SUBMITTER: Martinez-Lumbreras S
PROVIDER: S-EPMC4705658 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Martínez-Lumbreras Santiago S Taverniti Valerio V Zorrilla Silvia S Séraphin Bertrand B Pérez-Cañadillas José Manuel JM
Nucleic acids research 20151123 1
Metazoan SR and SR-like proteins are important regulatory factors in RNA splicing, export, translation and RNA decay. We determined the NMR structures and nucleic acid interaction modes of Gbp2 and Hrb1, two paralogous budding yeast proteins with similarities to mammalian SR proteins. Gbp2 RRM1 and RRM2 recognise preferentially RNAs containing the core motif GGUG. Sequence selectivity resides in a non-canonical interface in RRM2 that is highly related to the SRSF1 pseudoRRM. The atypical Gbp2/Hr ...[more]