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Neuropilin Functions as an Essential Cell Surface Receptor.

ABSTRACT: The Neuropilins (Nrps) are a family of essential cell surface receptors involved in multiple fundamental cellular signaling cascades. Nrp family members have key functions in VEGF-dependent angiogenesis and semaphorin-dependent axon guidance, controlling signaling and cross-talk between these fundamental physiological processes. More recently, Nrp function has been found in diverse signaling and adhesive functions, emphasizing their role as pleiotropic co-receptors. Pathological Nrp function has been shown to be important in aberrant activation of both canonical and alternative pathways. Here we review key recent insights into Nrp function in human health and disease.

SUBMITTER: Guo HF

PROVIDER: S-EPMC4705917 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Neuropilin Functions as an Essential Cell Surface Receptor.

Guo Hou-Fu HF Vander Kooi Craig W CW

The Journal of biological chemistry 20151008 49

The Neuropilins (Nrps) are a family of essential cell surface receptors involved in multiple fundamental cellular signaling cascades. Nrp family members have key functions in VEGF-dependent angiogenesis and semaphorin-dependent axon guidance, controlling signaling and cross-talk between these fundamental physiological processes. More recently, Nrp function has been found in diverse signaling and adhesive functions, emphasizing their role as pleiotropic co-receptors. Pathological Nrp function has ...[more]

PMID: 26451046

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