Ontology highlight
ABSTRACT:
SUBMITTER: Jiang H
PROVIDER: S-EPMC5779621 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Jiang Hao H López-Aguilar Aimé A Meng Lu L Gao Zhongwei Z Liu Yani Y Tian Xiao X Yu Guangli G Ovryn Ben B Moremen Kelley W KW Wu Peng P
Angewandte Chemie (International ed. in English) 20180102 4
Glycans anchored on cell-surface receptors are active modulators of receptor signaling. A strategy is presented that enforces transient changes to cell-surface glycosylation patterns to tune receptor signaling. This approach, termed in situ glycan editing, exploits recombinant glycosyltransferases to incorporate monosaccharides with linkage specificity onto receptors in situ. α2,3-linked sialic acid or α1,3-linked fucose added in situ suppresses signaling through epidermal growth factor receptor ...[more]