Ontology highlight
ABSTRACT:
SUBMITTER: Kwon YD
PROVIDER: S-EPMC4706170 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20150622 7
As the sole viral antigen on the HIV-1-virion surface, trimeric Env is a focus of vaccine efforts. Here we present the structure of the ligand-free HIV-1-Env trimer, fix its conformation and determine its receptor interactions. Epitope analyses revealed trimeric ligand-free Env to be structurally compatible with broadly neutralizing antibodies but not poorly neutralizing ones. We coupled these compatibility considerations with binding antigenicity to engineer conformationally fixed Envs, includi ...[more]