Ontology highlight
ABSTRACT:
SUBMITTER: Tagliamonte M
PROVIDER: S-EPMC3422313 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Tagliamonte Maria M Marasco Daniela D Ruggiero Alessia A De Stradis Angelo A Tornesello Maria Lina ML Totrov Maxim M Buonaguro Franco Maria FM Buonaguro Luigi L
PloS one 20120817 8
Heterologous protein scaffolds engrafted with structurally defined HIV Env epitopes recognized by broadly neutralizing monoclonal antibodies (MAbs) represent a promising strategy to elicit broad neutralizing antibodies. In such regards, a protein scaffold based on the HIV p24 CA protein is a highly attractive approach, providing also Gag epitopes for eliciting HIV non-neutralizing protective antibodies and specific CD4(+) and CD8(+) T cell responses. In the present study, computational technique ...[more]