Ontology highlight
ABSTRACT:
SUBMITTER: Deng C
PROVIDER: S-EPMC4706800 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Deng Changwang C Li Ying Y Zhou Lei L Cho Joonseok J Patel Bhavita B Terada Naohiro N Li Yangqiu Y Bungert Jörg J Qiu Yi Y Huang Suming S
Cell reports 20151224 1
Trithorax proteins and long-intergenic noncoding RNAs are critical regulators of embryonic stem cell pluripotency; however, how they cooperatively regulate germ layer mesoderm specification remains elusive. We report here that HoxBlinc RNA first specifies Flk1(+) mesoderm and then promotes hematopoietic differentiation through regulation of hoxb pathways. HoxBlinc binds to the hoxb genes, recruits Setd1a/MLL1 complexes, and mediates long-range chromatin interactions to activate transcription of ...[more]