Ontology highlight
ABSTRACT:
SUBMITTER: Little SR
PROVIDER: S-EPMC470709 | biostudies-literature | 2004 Jun
REPOSITORIES: biostudies-literature
Little Steven R SR Lynn David M DM Ge Qing Q Anderson Daniel G DG Puram Sidharth V SV Chen Jianzhu J Eisen Herman N HN Langer Robert R
Proceedings of the National Academy of Sciences of the United States of America 20040621 26
Current nonviral genetic vaccine systems are less effective than viral vaccines, particularly in cancer systems where epitopes can be weakly immunogenic and antigen-presenting cell processing and presentation to T cells is down-regulated. A promising nonviral delivery method for genetic vaccines involves microencapsulation of antigen-encoding DNA, because such particles protect plasmid payloads and target them to phagocytic antigen-presenting cells. However, conventional microparticle formulatio ...[more]