Ontology highlight
ABSTRACT:
SUBMITTER: Costa B
PROVIDER: S-EPMC4707509 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Costa Barbara B Da Pozzo Eleonora E Giacomelli Chiara C Barresi Elisabetta E Taliani Sabrina S Da Settimo Federico F Martini Claudia C
Scientific reports 20160111
The pharmacological activation of the cholesterol-binding Translocator Protein (TSPO) leads to an increase of endogenous steroids and neurosteroids determining benefic pleiotropic effects in several pathological conditions, including anxiety disorders. The relatively poor relationship between TSPO ligand binding affinities and steroidogenic efficacies prompted us to investigate the time (Residence Time, RT) that a number of compounds with phenylindolylglyoxylamide structure (PIGAs) spends in con ...[more]