Strong association of the polymorphisms in PBEF1 and knee OA risk: a two-stage population-based study in China.
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ABSTRACT:
SUBMITTER: Chu M
PROVIDER: S-EPMC4707545 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
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Strong association of the polymorphisms in PBEF1 and knee OA risk: a two-stage population-based study in China.
Chu Minjie M Rong Jiesheng J Wang Yidan Y Zhu Lin L Xing Baifen B Tao Yuchun Y Zhuang Xun X Zhao Yashuang Y Jiang Liying L
Scientific reports 20160111
The association of Pre-B cell colony enhancing factor 1 (PBEF1) with obesity, together with its pro-inflammatory properties suggests that PBEF1 might be another crucial mediator that links inflammation with obesity and primary osteoarthritis (OA). We hypothesized that polymorphisms in PBEF1 may modify the risk of developing OA. Thus we systematically screened 4 tagging polymorphisms (rs4730153, rs2058540, rs3801267 and rs16872158) in PBEF1 and evaluated the association between the genetic varian ...[more]
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