Ontology highlight
ABSTRACT:
SUBMITTER: Menon S
PROVIDER: S-EPMC4707677 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Menon Shalini S Boyer Nicholas Patrick NP Winkle Cortney Chelise CC McClain Leslie Marie LM Hanlin Christopher Carey CC Pandey Dharmendra D Pandey Dharmendra D Rothenfußer Simon S Taylor Anne Marion AM Gupton Stephanie Lynn SL
Developmental cell 20151201 6
Neuronal growth cone filopodia contain guidance receptors and contribute to axon guidance; however, the mechanism by which the guidance cue netrin increases filopodia density is unknown. Here, we demonstrate that TRIM9, an E3 ubiquitin ligase that localizes to filopodia tips and binds the netrin receptor DCC, interacts with and ubiquitinates the barbed-end polymerase VASP to modulate filopodial stability during netrin-dependent axon guidance. Studies with murine Trim9(+/+) and Trim9(-/-) cortica ...[more]