Ontology highlight
ABSTRACT:
SUBMITTER: Forster KM
PROVIDER: S-EPMC4708018 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Forster Karine M KM Hartwig Daiane D DD Oliveira Thaís L TL Bacelo Kátia L KL Schuch Rodrigo R Amaral Marta G MG Dellagostin Odir A OA
Memorias do Instituto Oswaldo Cruz 20151211 8
Leptospirosis is a zoonotic disease caused by pathogenic spirochetes of the Leptospira genus. Vaccination with bacterins has severe limitations. Here, we evaluated the N-terminal region of the leptospiral immunoglobulin-like B protein (LigBrep) as a vaccine candidate against leptospirosis using immunisation strategies based on DNA prime-protein boost, DNA vaccine, and subunit vaccine. Upon challenge with a virulent strain ofLeptospira interrogans, the prime-boost and DNA vaccine approaches induc ...[more]