Ontology highlight
ABSTRACT:
SUBMITTER: Wang Z
PROVIDER: S-EPMC4709245 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Wang Zhongliang Z Wang Zhe Z Liu Dingbin D Yan Xuefeng X Wang Fu F Niu Gang G Yang Min M Chen Xiaoyuan X
Angewandte Chemie (International ed. in English) 20140120 7
RNA interference (RNAi) is an RNA-dependent gene silencing approach controlled by an RNA-induced silencing complex (RISC). Herein, we present a synthetic RISC-mimic nanocomplex, which can actively cleave its target RNA in a sequence-specific manner. With high enzymatic stability and efficient self-delivery to target cells, the designed nanocomplex can selectively and potently induce gene silencing without cytokine activation. These nanocomplexes, which target multidrug resistance, are not only a ...[more]