Ontology highlight
ABSTRACT:
SUBMITTER: Paredes F
PROVIDER: S-EPMC4710961 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Paredes Felipe F Parra Valentina V Torrealba Natalia N Navarro-Marquez Mario M Gatica Damian D Bravo-Sagua Roberto R Troncoso Rodrigo R Pennanen Christian C Quiroga Clara C Chiong Mario M Caesar Christa C Taylor W Robert WR Molgó Jordi J San Martin Alejandra A Jaimovich Enrique E Lavandero Sergio S
Free radical biology & medicine 20151123
Homocysteine-inducible, endoplasmic reticulum (ER) stress-inducible, ubiquitin-like domain member 1 (HERPUD1), an ER resident protein, is upregulated in response to ER stress and Ca(2+) homeostasis deregulation. HERPUD1 exerts cytoprotective effects in various models, but its role during oxidative insult remains unknown. The aim of this study was to investigate whether HERPUD1 contributes to cytoprotection in response to redox stress and participates in mediating stress-dependent signaling pathw ...[more]