Ontology highlight
ABSTRACT:
SUBMITTER: Schutze T
PROVIDER: S-EPMC4712676 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Schütze Tonio T Ulrich Alexander K C AK Apelt Luise L Will Cindy L CL Bartlick Natascha N Seeger Martin M Weber Gert G Lührmann Reinhard R Stelzl Ulrich U Wahl Markus C MC
RNA (New York, N.Y.) 20151216 2
Spliceosomal Prp38 proteins contain a conserved amino-terminal domain, but only higher eukaryotic orthologs also harbor a carboxy-terminal RS domain, a hallmark of splicing regulatory SR proteins. We show by crystal structure analysis that the amino-terminal domain of human Prp38 is organized around three pairs of antiparallel α-helices and lacks similarities to RNA-binding domains found in canonical SR proteins. Instead, yeast two-hybrid analyses suggest that the amino-terminal domain is a vers ...[more]