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Regulatory T Cell Immunotherapy in Immune-Mediated Diseases.

ABSTRACT: Broad clinical interest rapidly followed the recent discovery of different subpopulations of T cells that have immune regulatory properties and a number of studies have been conducted aiming to dissect the translational potential of these promising cells. In this review we will focus on forkhead box P3 (FoxP3) positive regulatory T cells, T regulatory type 1 cells and invariant natural killer T cells (iNKT). We will analyze their ability to correct immune dysregulation in animal models of immune mediated diseases and we will examine the first clinical approaches where these cells have been directly or indirectly employed. We will discuss successes, challenges and limitations that rose in the road to the clinical use of regulatory T cells.

SUBMITTER: Pierini A

PROVIDER: S-EPMC4712720 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Regulatory T Cell Immunotherapy in Immune-Mediated Diseases.

Pierini Antonio A Schneidawind Dominik D Nishikii Hidekazu H Negrin Robert S RS

Current stem cell reports 20150912 4

Broad clinical interest rapidly followed the recent discovery of different subpopulations of T cells that have immune regulatory properties and a number of studies have been conducted aiming to dissect the translational potential of these promising cells. In this review we will focus on forkhead box P3 (FoxP3) positive regulatory T cells, T regulatory type 1 cells and invariant natural killer T cells (iNKT). We will analyze their ability to correct immune dysregulation in animal models of immune ...[more]

PMID: 26779417

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