Ontology highlight
ABSTRACT:
SUBMITTER: Di Marco M
PROVIDER: S-EPMC4714146 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Di Marco Mariacristina M Grassi Elisa E Durante Sandra S Vecchiarelli Silvia S Palloni Andrea A Macchini Marina M Casadei Riccardo R Ricci Claudio C Panzacchi Riccardo R Santini Donatella D Biasco Guido G
World journal of gastrointestinal oncology 20160101 1
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies with a five-year survival rate of approximately 5%. Several target agents have been tested in PDAC, but almost all have failed to demonstrate efficacy in late phase clinical trials, despite the better understanding of PDAC molecular biology generated by large cancer sequencing initiatives in the past decade. Eroltinib (a small-molecule tyrosine-kinase inhibitor of epidermal growth factor receptor) plus gemcitabine is ...[more]