Ontology highlight
ABSTRACT:
SUBMITTER: Kachuri L
PROVIDER: S-EPMC4715236 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Kachuri Linda L Amos Christopher I CI McKay James D JD Johansson Mattias M Vineis Paolo P Bueno-de-Mesquita H Bas HB Boutron-Ruault Marie-Christine MC Johansson Mikael M Quirós J Ramón JR Sieri Sabina S Travis Ruth C RC Weiderpass Elisabete E Le Marchand Loic L Henderson Brian E BE Wilkens Lynne L Goodman Gary E GE Chen Chu C Doherty Jennifer A JA Christiani David C DC Wei Yongyue Y Su Li L Tworoger Shelley S Zhang Xuehong X Kraft Peter P Zaridze David D Field John K JK Marcus Michael W MW Davies Michael P A MPA Hyde Russell R Caporaso Neil E NE Landi Maria Teresa MT Severi Gianluca G Giles Graham G GG Liu Geoffrey G McLaughlin John R JR Li Yafang Y Xiao Xiangjun X Fehringer Gord G Zong Xuchen X Denroche Robert E RE Zuzarte Philip C PC McPherson John D JD Brennan Paul P Hung Rayjean J RJ
Carcinogenesis 20151120 1
Chromosome 5p15.33 has been identified as a lung cancer susceptibility locus, however the underlying causal mechanisms were not fully elucidated. Previous fine-mapping studies of this locus have relied on imputation or investigated a small number of known, common variants. This study represents a significant advance over previous research by investigating a large number of novel, rare variants, as well as their underlying mechanisms through telomere length. Variants for this fine-mapping study w ...[more]