Ontology highlight
ABSTRACT:
SUBMITTER: Ellinghaus D
PROVIDER: S-EPMC3797441 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Nature genetics 20130602 7
Atopic dermatitis is a common inflammatory skin disease with a strong heritable component. Pathogenetic models consider keratinocyte differentiation defects and immune alterations as scaffolds, and recent data indicate a role for autoreactivity in at least a subgroup of patients. FLG (encoding filaggrin) has been identified as a major locus causing skin barrier deficiency. To better define risk variants and identify additional susceptibility loci, we densely genotyped 2,425 German individuals wi ...[more]