Ontology highlight
ABSTRACT:
SUBMITTER: Kung VM
PROVIDER: S-EPMC4715541 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Kung Vanessa M VM Cornilescu Gabriel G Gellman Samuel H SH
Angewandte Chemie (International ed. in English) 20151012 48
We have examined whether parallel β-sheet secondary structure becomes more stable as the number of β-strands increases, via comparisons among peptides designed to adopt two- or three-stranded parallel β-sheet conformations in aqueous solution. Our three-strand design is the first experimental model of a triple-stranded parallel β-sheet. Analysis of the designed peptides by nuclear magnetic resonance (NMR) and circular dichroism (CD) spectroscopy supports the hypothesis that increasing the number ...[more]