Ontology highlight
ABSTRACT:
SUBMITTER: Neau DB
PROVIDER: S-EPMC4715880 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Neau David B DB Gilbert Nathaniel C NC Bartlett Sue G SG Boeglin William W Brash Alan R AR Newcomer Marcia E ME
Biochemistry 20090801 33
Lipoxygenases (LOX) play pivotal roles in the biosynthesis of leukotrienes and other biologically active eicosanoids derived from arachidonic acid. A mechanistic understanding of substrate recognition, when lipoxygenases that recognize the same substrate generate different products, can be used to help guide the design of enzyme-specific inhibitors. We report here the 1.85 A resolution structure of an 8R-lipoxygenase from Plexaura homomalla, an enzyme with a sequence approximately 40% identical ...[more]