A Systems Pharmacology Model for Predicting Effects of Factor Xa Inhibitors in Healthy Subjects: Assessment of Pharmacokinetics and Binding Kinetics.
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ABSTRACT:
SUBMITTER: Zhou X
PROVIDER: S-EPMC4716584 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
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A Systems Pharmacology Model for Predicting Effects of Factor Xa Inhibitors in Healthy Subjects: Assessment of Pharmacokinetics and Binding Kinetics.
Zhou X X Huntjens Drh D Gilissen Rahj R
CPT: pharmacometrics & systems pharmacology 20151009 11
Factor Xa (FXa) emerged as a promising target for effective anticoagulation and several FXa inhibitors are now available for the prevention of venous thromboembolism. However, in previously reported pharmacokinetic/pharmacodynamic (PK/PD) models, the complex coagulation processes and detailed information of drug action are usually unclear, which makes it difficult to predict clinical outcome at the drug discovery stage. In this study, a large-scale systems pharmacology model was developed based ...[more]
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