Ontology highlight
ABSTRACT:
SUBMITTER: McNulty J
PROVIDER: S-EPMC4716588 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
McNulty James J D'Aiuto Leonardo L Zhi Yun Y McClain Lora L Zepeda-Velázquez Carlos C Ler Spencer S Jenkins Hilary A HA Yee Michael B MB Piazza Paolo P Yolken Robert H RH Kinchington Paul R PR Nimgaonkar Vishwajit L VL
ACS medicinal chemistry letters 20151119 1
The Amaryllidaceae alkaloid trans-dihydrolycoricidine 7 and three analogues 8-10 were produced via asymmetric chemical synthesis. Alkaloid 7 proved superior to acyclovir, the current standard for herpes simplex virus, type 1 (HSV-1) infection. Compound 7 potently inhibited lytic HSV-1 infection, significantly reduced HSV-1 reactivation, and more potently inhibited varicella zoster virus (VZV) lytic infection. A configurationally defined (3R)-secondary alcohol at C3 proved crucial for efficacious ...[more]