Ontology highlight
ABSTRACT:
SUBMITTER: Ackermann M
PROVIDER: S-EPMC6269475 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Ackermann Mania M Kempf Henning H Hetzel Miriam M Hesse Christina C Hashtchin Anna Rafiei AR Brinkert Kerstin K Schott Juliane Wilhelmine JW Haake Kathrin K Kühnel Mark Philipp MP Glage Silke S Figueiredo Constanca C Jonigk Danny D Sewald Katherina K Schambach Axel A Wronski Sabine S Moritz Thomas T Martin Ulrich U Zweigerdt Robert R Munder Antje A Lachmann Nico N
Nature communications 20181130 1
The increasing number of severe infections with multi-drug-resistant pathogens worldwide highlights the need for alternative treatment options. Given the pivotal role of phagocytes and especially alveolar macrophages in pulmonary immunity, we introduce a new, cell-based treatment strategy to target bacterial airway infections. Here we show that the mass production of therapeutic phagocytes from induced pluripotent stem cells (iPSC) in industry-compatible, stirred-tank bioreactors is feasible. Bi ...[more]