Ontology highlight
ABSTRACT:
SUBMITTER: Anyika M
PROVIDER: S-EPMC4716602 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20151209 1
KU-32 and KU-596 are novobiocin-derived, C-terminal heat shock protein 90 (Hsp90) modulators that induce Hsp70 levels and manifest neuroprotective activity. However, the synthetically complex noviose sugar requires 10 steps to prepare, which makes translational development difficult. In this study, we developed a series of "noviomimetic" analogues of KU-596, which contain noviose surrogates that can be easily prepared, while maintaining the ability to induce Hsp70 levels. Both sugar and sugar an ...[more]