Ontology highlight
ABSTRACT:
SUBMITTER: Kumar Mv V
PROVIDER: S-EPMC6097425 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
MedChemComm 20180702 8
Unique to targeting the C-terminal domain of Hsp90 (C-Hsp90) is the ability to uncouple the cytotoxic and cytoprotective outcomes of Hsp90 modulation. After the identification of novobiocin as a C-Hsp90 interacting ligand a diverse gamut of novologues emerged, from which KU-32 and KU-596 exhibited strong neuroprotective activity. However, further development of these ligands is hampered by the difficulty to obtain structural information on their complexes with Hsp90. Using saturation transfer di ...[more]