Ontology highlight
ABSTRACT:
SUBMITTER: Engel J
PROVIDER: S-EPMC4716607 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20151218 1
In the last five years, the detailed understanding of how to overcome T790M drug resistance in non-small cell lung cancer (NSCLC) has culminated in the development of a third-generation of covalent EGFR inhibitors with excellent clinical outcomes. However, the emergence of a newly discovered acquired drug resistance challenges the concept of small molecule targeted cancer therapy in NSCLC. ...[more]