Ontology highlight
ABSTRACT:
SUBMITTER: Ohashi Y
PROVIDER: S-EPMC5788588 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Ohashi Yoshimi Y Okamura Mutsumi M Katayama Ryohei R Fang Siyang S Tsutsui Saki S Akatsuka Akinobu A Shan Mingde M Choi Hyeong-Wook HW Fujita Naoya N Yoshimatsu Kentaro K Shiina Isamu I Yamori Takao T Dan Shingo S
Oncotarget 20171206 2
Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (EGFR-TKIs) were demonstrated to provide survival benefit in patients with non-small cell lung cancer (NSCLC) harboring activating mutations of EGFR; however, emergence of acquired resistance to EGFR-TKIs has been shown to cause poor outcome. To overcome the TKI resistance, drugs with different mode of action are required. We previously reported that M-COPA (2-methylcoprophilinamide), a Golgi disruptor, suppressed the growth of g ...[more]