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Synthesis and Evaluation of 2,6-Modified Purine 2'-C-Methyl Ribonucleosides as Inhibitors of HCV Replication.

ABSTRACT: A variety of 2,6-modified purine 2'-C-methylribonucleosides and their phosphoramidate prodrugs were synthesized and evaluated for inhibition of HCV RNA replication in Huh-7 cells and for cytotoxicity in various cell lines. Cellular pharmacology and HCV polymerase incorporation studies on the most potent and selective compound are reported.

SUBMITTER: Zhou L

PROVIDER: S-EPMC4716611 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature

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Synthesis and Evaluation of 2,6-Modified Purine 2'-C-Methyl Ribonucleosides as Inhibitors of HCV Replication.

Zhou Longhu L Zhang Hongwang H Tao Sijia S Ehteshami Maryam M Cho Jong Hyun JH McBrayer Tamara R TR Tharnish Philip P Whitaker Tony T Amblard Franck F Coats Steven J SJ Schinazi Raymond F RF

ACS medicinal chemistry letters 20151123 1

A variety of 2,6-modified purine 2'-C-methylribonucleosides and their phosphoramidate prodrugs were synthesized and evaluated for inhibition of HCV RNA replication in Huh-7 cells and for cytotoxicity in various cell lines. Cellular pharmacology and HCV polymerase incorporation studies on the most potent and selective compound are reported. ...[more]

PMID: 26819659

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