Ontology highlight
ABSTRACT:
SUBMITTER: Skacel J
PROVIDER: S-EPMC10226123 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20230503 10
Purine nucleoside phosphorylase (PNP) is a well-known molecular target with potential therapeutic applications in the treatment of T-cell malignancies and/or bacterial/parasitic infections. Here, we report the design, development of synthetic methodology, and biological evaluation of a series of 30 novel PNP inhibitors based on acyclic nucleoside phosphonates bearing a 9-deazahypoxanthine nucleobase. The strongest inhibitors exhibited IC<sub>50</sub> values as low as 19 nM (human PNP) and 4 nM ( ...[more]