The prognostic effect of PTEN expression status in colorectal cancer development and evaluation of factors affecting it: miR-21 and promoter methylation.
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ABSTRACT:
SUBMITTER: Yazdani Y
PROVIDER: S-EPMC4717643 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Publications
The prognostic effect of PTEN expression status in colorectal cancer development and evaluation of factors affecting it: miR-21 and promoter methylation.
Yazdani Yaghoub Y Farazmandfar Touraj T Azadeh Hossein H Zekavatian Zeinab Z
Journal of biomedical science 20160119
<h4>Background</h4>PTEN is a tumor suppressor gene which is involved in cellular proliferation, differentiation, and apoptosis. Loss or down-regulation of PTEN plays an important role in human cancers development. In this study, we investigated the effect of miR-21 and promoter methylation on the PTEN expression status in CRC tissues and analyzed association of the PTEN expression status with clinicopathological features in patients with CRC.<h4>Results</h4>The PTEN expression was positively det ...[more]
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