Ontology highlight
ABSTRACT:
SUBMITTER: Shi M
PROVIDER: S-EPMC4717672 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Nature 20110615 7351
Transforming growth factor (TGF)-β is stored in the extracellular matrix as a latent complex with its prodomain. Activation of TGF-β1 requires the binding of α(v) integrin to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-β binding proteins. Crystals of dimeric porcine proTGF-β1 reveal a ring-shaped complex, a novel fold for the prodomain, and show how the prodomain shields the growth factor from recognition by recep ...[more]