Ontology highlight
ABSTRACT:
SUBMITTER: Campbell MG
PROVIDER: S-EPMC7238552 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Cell 20200116 3
Integrin αvβ8 binds with exquisite specificity to latent transforming growth factor-β (L-TGF-β). This binding is essential for activating L-TGF-β presented by a variety of cell types. Inhibiting αvβ8-mediated TGF-β activation blocks immunosuppressive regulatory T cell differentiation, which is a potential therapeutic strategy in cancer. Using cryo-electron microscopy, structure-guided mutagenesis, and cell-based assays, we reveal the binding interactions between the entire αvβ8 ectodomain and it ...[more]