Unknown

Dataset Information

0

Diagnostic and Prognostic Value of Serum Interleukin-6 in Colorectal Cancer.


ABSTRACT: The application of serum interleukin-6 (IL-6) in the diagnosis and prognosis of colorectal cancer (CRC) has been evaluated in many studies, whereas the results were contradictive.The aim of this study was to systematically evaluate this issue.An original study was conducted to explore the diagnostic value of serum IL-6 in CRC. Pubmed, Embase, and Cochrane library databases were searched for eligible studies.For diagnostic meta-analysis, aggregate data (AD) and individual participant data (IPD) meta-analyses were both adopted. The sensitivity and specificity were pooled and a summary receiver-operating characteristic (ROC) curve was constructed. For prognostic meta-analysis, study-specific hazard ratios (HRs) of IL-6 for survival were summarized. Secondary analysis of survival data was performed to synthesize the Kaplan-Meier curves.Total 17 studies (including our study) were included in this meta-analysis. The pooled sensitivity, specificity, and area under curve (AUC) of serum IL-6 were 0.72 (95% CI: 0.46-0.88), 0.74 (95% CI: 0.56-0.86), and 0.79 (95% CI: 0.75-0.82) in CRC diagnosis, respectively. Further, IPD meta-analysis strengthened the diagnostic value of serum IL-6 (the AUC, sensitivity, and specificity were 0.794, 0.606, and 0.839, respectively). For prognostic analysis, the high serum level of IL-6 was inversely associated with overall survival (OS) (pooled HR?=?1.76, 95% CI: 1.42-2.19, P?

SUBMITTER: Xu J 

PROVIDER: S-EPMC4718291 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

Diagnostic and Prognostic Value of Serum Interleukin-6 in Colorectal Cancer.

Xu Jinming J   Ye Yao Y   Zhang Honghe H   Szmitkowski Maciej M   Mäkinen M J MJ   Li Peiwei P   Xia Dajing D   Yang Jun J   Wu Yihua Y   Wu Han H  

Medicine 20160101 2


The application of serum interleukin-6 (IL-6) in the diagnosis and prognosis of colorectal cancer (CRC) has been evaluated in many studies, whereas the results were contradictive.The aim of this study was to systematically evaluate this issue.An original study was conducted to explore the diagnostic value of serum IL-6 in CRC. Pubmed, Embase, and Cochrane library databases were searched for eligible studies.For diagnostic meta-analysis, aggregate data (AD) and individual participant data (IPD) m  ...[more]

Similar Datasets

2024-09-15 | GSE276849 | GEO
| S-EPMC4391830 | biostudies-literature
| S-EPMC5354890 | biostudies-other
| S-EPMC6451835 | biostudies-literature
| S-EPMC7225793 | biostudies-literature
| S-EPMC3687369 | biostudies-literature
| S-EPMC8230660 | biostudies-literature
| S-EPMC7164426 | biostudies-literature
| S-EPMC4021260 | biostudies-literature
| S-EPMC7400983 | biostudies-literature