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Ruthenium(0)-Catalyzed [4+2] Cycloaddition of Acetylenic Aldehydes with ?-Ketols: Convergent Construction of Angucycline Ring Systems.

ABSTRACT: Ruthenium(0) complexes modified by CyJohnPhos or RuPhos catalyze the successive C-C coupling of acetylenic aldehydes with ?-ketols to form [4+2] cycloadducts as single diastereomers. This method enables convergent construction of type?II polyketide ring systems of the angucycline class.

SUBMITTER: Saxena A

PROVIDER: S-EPMC4718903 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature

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Ruthenium(0)-Catalyzed [4+2] Cycloaddition of Acetylenic Aldehydes with α-Ketols: Convergent Construction of Angucycline Ring Systems.

Saxena Aakarsh A Perez Felix F Krische Michael J MJ

Angewandte Chemie (International ed. in English) 20151209 4

Ruthenium(0) complexes modified by CyJohnPhos or RuPhos catalyze the successive C-C coupling of acetylenic aldehydes with α-ketols to form [4+2] cycloadducts as single diastereomers. This method enables convergent construction of type II polyketide ring systems of the angucycline class. ...[more]

PMID: 26663806

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