Ontology highlight
ABSTRACT:
SUBMITTER: Kawabata S
PROVIDER: S-EPMC4719132 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Kawabata Soya S Takano Morito M Numasawa-Kuroiwa Yuko Y Itakura Go G Kobayashi Yoshiomi Y Nishiyama Yuichiro Y Sugai Keiko K Nishimura Soraya S Iwai Hiroki H Isoda Miho M Shibata Shinsuke S Kohyama Jun J Iwanami Akio A Toyama Yoshiaki Y Matsumoto Morio M Nakamura Masaya M Okano Hideyuki H
Stem cell reports 20151224 1
Murine- and human-induced pluripotent stem cell-derived neural stem/progenitor cells (iPSC-NS/PCs) promote functional recovery following transplantation into the injured spinal cord in rodents and primates. Although remyelination of spared demyelinated axons is a critical mechanism in the regeneration of the injured spinal cord, human iPSC-NS/PCs predominantly differentiate into neurons both in vitro and in vivo. We therefore took advantage of our recently developed protocol to obtain human-indu ...[more]